Title: Clots destroying the blood-brain barrier
Votes: 7
Views: 26
Description: We used a 2-photon microscope to image the cerebral cortex through an intact skull to visualise the leakiness of the neurovasculature after a stroke in mice. We injected Cy7-loaded particles (blue) into a mouse intravenously after a pre-clinical model of stroke. The subsequent blood clots (white) generated from the stroke mode caused the neurovasculature (red) to lose its integrity, causing our dye to leak out into the brain parenchyma. This exacerbates the activation of microglia (green), the resident immune cell in the brain, to worsen stroke outcome.